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118 Inhibiting CCR5 in vitro and in vivo

Moore, John

JAIDS Journal of Acquired Immune Deficiency Syndromes: April 2011 - Volume 56 - Issue - p 47
doi: 10.1097/01.qai.0000397306.86718.85


I will describe collaborative research on CCR5 small molecule inhibitors of HIV-1 entry. In particular I will discuss how HIV-1 develops resistance to this drug class in vitro. I will also show how these compounds can be used to prevent HIV-1 transmission in the macaque model when applied as a vaginal microbicide, both as a gel and as a vaginal ring. I will also address how such approaches can be combined with vaccination to make a more effective prevention science strategy.

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