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CME Posttest: HIV and Cardiometabolic Abnormalities: New Perspectives and Treatment Update

JAIDS Journal of Acquired Immune Deficiency Syndromes: September 1st, 2008 - Volume 49 - Issue - p S101
doi: 10.1097/QAI.0b013e3181865275
  • 1. Which statement best describes the lipid-related findings of the Multicenter AIDS Cohort Study (MACS) trial?
    • a. Highly active antiretroviral therapy (HAART) caused a significant rise in total cholesterol and low-density lipoprotein cholesterol (LDL-C) compared with preinfection levels.
    • b. Serum levels of total cholesterol, LDL-C, and high-density lipoprotein cholesterol (HDL-C) decreased upon infection with HIV.
    • c. Serum levels of total cholesterol and LDL-C decreased upon initiation of HAART.
    • d. Levels of HDL-C increased significantly upon initiation of HAART.
    • e. Triglyceride levels were significantly elevated upon both infection and initiation of HAART.
  • 2. The Data Collection on Adverse Events of Anti-HIV Drugs (DAD) study of myocardial infarction (MI) risk found that:
    • a. Patients demonstrated a high level of cardiovascular risk at baseline.
    • b. A progressive increase in risk of MI was associated with increased length of antiretroviral therapy.
    • c. Protease inhibitors demonstrated an increased risk for MI compared with nonnucleoside reverse transcriptase inhibitors.
    • d. Increase in cardiovascular risk was related to concentrations of serum lipids.
    • e. All of the above
  • 3. Which of the following is not a risk factor for the development of type 2 diabetes?
    • a. Older age
    • b. Hypertension
    • c. High levels of HDL-C and low levels of triglycerides
    • d. Decreased physical activity
    • e. Having a first-degree relative with diabetes
  • 4. Which of the following statements concerning the management of diabetes in HIV-infected patients is false?
    • a. The weight loss associated with metformin can improve HIV-related lipoatrophy.
    • b. Losing weight and increasing physical activity are recommended as first-line therapy.
    • c. Standards of care for diabetes are similar to those for non-HIV-infected patients.
    • d. A 1.5% improvement of A1C levels is expected with metformin.
    • e. Use of glitazones is generally not recommended for individuals with significant cardiovascular disease.
  • 5. Which of the following interventions is not among those used to treat lipohypertrophy?
    • a. Tesamorelin
    • b. Weight loss
    • c. Elimination of thymidine analogs
    • d. Human growth hormone
    • e. Metformin
  • 6. Dietary supplementation with _________ can improve HIV-related lipoatrophy.
    • a. Unsaturated fats
    • b. Trans fats
    • c. Cytosine
    • d. Uridine
    • e. Phenylalanine
© 2008 Lippincott Williams & Wilkins, Inc.