aEscola Paulista de Medicina, Universidade Federal de SĂ£o Paulo, SĂ£o Paulo, Brazil
bFaculdade de Medicina da Universidade de SĂ£o Paulo, SĂ£o Paulo, Brazil
cCentro de ReferĂªncia e Treinamento DST/Aids, Sao Paulo, Brazil
dProjeto Praça Onze, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil
R.S.D. has received research grants from ViiV, Sanofi, J&J, and Gilead and has received honoraria for participating in GSK, ViiV, MSD, Janssen, and Gilead advisory boards; D.L.E. has received honoraria for participating in GSK, ViiV, and Gilead and advisory boards; MS has received research grants from ViiV, GSK, Janssen, MSD, and Gilead and has received honoraria for participating in GSK, ViiV, MSD, Janssen, and Gilead advisory boards. The remaining authors have no funding or conflicts of interest to disclose.
R.S.D. led the project, designed the laboratory experiments, oversaw their implementation, commented on and edited early versions of the manuscript, and read and approved the final manuscript; A.G. designed and led the PrEp demonstration project and read and approved the final manuscript; D.L.E. participated in the design of the PrEP demonstration project, patient follow-up, and read and approved the final manuscript; J.G. and D.D. conducted the laboratory experiments and read and approved the final manuscript; MS reviewed and analyzed the data and wrote the manuscript.