^*Infectious Diseases Department, University Hospital, Montpellier, France

^†Institute of Human Genetics, UMR9002, CNRS-Montpellier University, Montpellier, France

^‡Currently, European Hospital, Marseille, France

^§Microbiology Department, University Hospital, Montpellier, France

^║Montpellier University, Montpellier, France

^¶UMR U1058, INSERM-EFS, France

^#Medical Informatics Department, University Hospital, Montpellier, France

^**UMI 233, IRD-INSERM U1175-Montpellier University, France

^††Immunology Department, University Hospital, Nîmes, France

Supported by MSD-Avenir and by the University Hospitals of Montpellier and Nimes. The funding source was involved neither in the study design, nor in collection, analysis, interpretation of data, nor in the decision to submit the article for publication.

The authors have no funding or conflicts of interest to disclose.

C.P. contributed to the conception and design of the study, the patients' enrollment, and acquired, analyzed, and interpreted data. E.T. contributed to the conception and design of the flow cytometry study and acquired, analyzed, and interpreted data on cell surface markers. G.M. contributed to the conception and design of the statistical study and acquired, analyzed, and interpreted statistical data. J.R. contributed to the conception and design of the study, and analyzed and interpreted data. P.C. contributed to the conception and design of the study, analyzed and interpreted data, and wrote the first draft of the manuscript.

The Ethics Committee of Sud Méditerranée IV has approved the study. Informed, written consent has been obtained from the patients.

Received September 17, 2018

Accepted September 24, 2018