aDepartment of Global Health, University of Washington, Seattle, WA;
bDepartment of Medicine, University of Washington, Seattle, WA;
cDepartment of Epidemiology, University of Washington, Seattle, WA;
dNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom;
eEThekwini Municipality Health Unit, EThekwini Municipality, Durban KwaZulu-Natal, South Africa;
fDepartment of Psychology, University of Washington, Seattle, WA;
gCentre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa; and
hDiscipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.
Correspondence to: Paul K. Drain, MD, MPH, 325 Ninth Ave, UW Box 359927, Seattle, WA 98104-2420 (e-mail: [email protected]).
Funding: National Institute of Allergy and Infectious Diseases (R21AI124719), the Center for AIDS Research at the University of Washington (P30 AI027757), and the South African National Health Laboratory Service Research Trust (2018-1DEVPMO01). J.D. is supported by the Wellcome Trust (Grant number 216421/Z/19/Z).
P.K.D. reports receiving research support, paid to his institution, from the NIH, CDC, Gilead Sciences, and the Bill and Melinda Gates Foundation, during the conduct of the study. All authors declare that they have no competing interests.
P.K.D. and N.G. conceived the trial and are the coprincipal investigators. P.K.D., N.G., J.D., J.Q.A., and K.T. designed the study. N.G., J.D., P.K.D., N.M., J.Q.A., and L.V. implemented the study and acquired the data. K.T. and L.V. performed the statistical analysis. M.W. and P.K.D. wrote the initial manuscript draft. All authors critically revised the manuscript and consented to final publication.
ClinicalTrials.gov registration: NCT03066128, registered February 22, 2017.