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A-102 Antibody binding to HIV-1 infected cells as mechanism for treatment of HIV infection

Ferrari, Guido, MD*; Nordstrom, Jeffrey, PhD.; Koenig, Scott, MD; Sung, Julia, MD; Margolis, David, MD; Haynes, Barton, MD§

JAIDS Journal of Acquired Immune Deficiency Syndromes: April 2018 - Volume 77 - Issue - p 33
doi: 10.1097/01.qai.0000532483.69631.d6
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Anti-HIV antibody function is not limited to capturing free virus but also includes the recognition of HIV-1 infected cells. Both neutralizing and nonneutralizing antibody responses recognizing HIV-1 envelope epitopes expressed on the cellular membrane can recruit Fc receptor-bearing cells and direct their cytotoxic activity against the infected cells. We can leverage on our ability to use monoclonal antibody and monoclonal antibody-based molecules to protect from and treat HIV-1 infection.

*Duke University;

Macrogenics;

University of North Carolina—Chapel Hill; and

§Duke University Medical Center

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