On behalf of a team of researchers at WMCM, the AMC (Amsterdam) and the Scripps Research Institute, I will discuss in vitro and animal immunization studies involving native-like SOSIP.664 trimers. In some cases, the properties and performance of these proteins will be compared and contrasted with other, non-native forms of Env. The ultimate goal of the SOSIP. trimer program is to induce broadly neutralizing antibodies, which has not yet been achieved. Strategies towards this goal will be discussed.
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