There is growing evidence that early antiretroviral therapy can induce a state of “post treatment control” in which HIV viraemia remains suppressed when ART is stopped. The possibility that in some individuals HIV viraemia does not return within days after treatment interruption challenges much of our current understanding of HIV persistence. This presentation will review the evidence for PTC, and consider its likely prevalence, mechanism and mode of induction. Data will be presented from studies of individuals given ART in primary infection, and will explore the potential for potential biomarkers that might be used in clinical practice to identify patients who might exhibit PTC. Consideration will be given to the significance of PTC and how it might inform future cure strategies.
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