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Prevalent Tuberculosis at HIV Diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) Cohort

Saraceni, Valeria MD, PhD*; Cohn, Silvia MS; Cavalcante, Solange C. MD, PhD*,‡; Pacheco, Antonio G. F. MD, PhD; Moulton, Lawrence H. PhD†,§; Chaisson, Richard E. MD†,§; Durovni, Betina MD, MPH*,‖; Golub, Jonathan E. PhD, MPH†,§

JAIDS Journal of Acquired Immune Deficiency Syndromes: September 1st, 2014 - Volume 67 - Issue 1 - p 98–101
doi: 10.1097/QAI.0000000000000247
Epidemiology and Prevention

Background: Although Brazil has model HIV care programs, many patients continue to present late to care. We studied the frequency of tuberculosis (TB) diagnosed at HIV diagnosis in Rio de Janeiro, Brazil, to quantify missed opportunities for TB prevention.

Methods: People living with HIV (PLHIV) and enrolled in the TB/HIV in Rio study between September 1, 2005, and August 31, 2009, were included. Prevalent TB was defined as TB diagnosed within 60 days of HIV diagnosis or HIV diagnosis during TB therapy. Survival was measured from HIV diagnosis. We conducted Kaplan–Meier survival plots and Cox regression analyses.

Results: Four thousand five hundred forty-eight newly diagnosed PLHIV were enrolled: 476 (10.5%) with prevalent TB. Individuals with prevalent TB were older, had lower CD4 counts, and higher viral loads than did those without TB. Median time to receiving highly active antiretroviral therapy (HAART) in those with prevalent TB was 99 days (interquartile range = 58–191) vs. 126 days (interquartile range = 63–301) in those without TB (P = 0.021). Among those with prevalent TB, 17% died during follow-up compared with 8% among those without TB (P < 0.001). After adjustment for sex, age, baseline CD4, and baseline viral load, the risk of occurrence of death remained significantly higher among those with prevalent TB [adjusted hazard ratio = 1.72 (confidence interval 95% 1.19 to 2.48)].

Conclusions: More than 10% of new PLHIV in our study presented to care with concurrent active TB disease and thus missed the opportunity for undergoing TB preventive therapy. Despite initiating HAART more quickly, these individuals were at a significantly greater risk of death. Earlier HIV diagnosis is necessary to provide earlier initiation of HAART and TB preventive therapy to reduce morbidity and mortality in PLHIV.

*Rio de Janeiro City Health Secretariat, Rio de Janeiro, Brazil;

Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD;

FIOCRUZ, PROCC, Rio de Janeiro, Brazil;

§Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; and

Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Correspondence to: Jonathan E. Golub, PhD, MPH, Center for Tuberculosis Research, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231 (e-mail:

Supported by the Bill & Melinda Gates Foundation Grant for the Consortium to Respond Effectively to the AIDS/TB Epidemic (CREATE) and National Institutes of Health Grants AI066994, AI001637, and the International Clinical Operational and Health Services Research and Training Award (ICOHRTA), 5U2RTW006885.

The authors have no conflicts of interest to disclose.

V.S., J.E.G., and R.E.C. drafted the manuscript; V.S., B.D., J.E.G., S.C., L.H.M., and A.G.P. conducted or contributed to the analyses; All authors contributed to data interpretation and drafting of the manuscript.

Received May 23, 2014

Accepted May 23, 2014

© 2014 by Lippincott Williams & Wilkins