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Functionally Defective High-Density Lipoproteins Are Related to Heightened T-Cell Activation in Vertically HIV-Infected Adolescents

Sainz, Talía MD*; Ortega-Hernández, Adriana BSc; Serrano-Villar, Sergio MD, PhD; Navarro, María L. MD, PhD§; Rojo, Pablo MD, PhD; Ramos, José T. MD, PhD; Mellado, María J. MD, PhD#; Diaz, Laura PhD*; Alvarez, Maria MD*; Estrada, Vicente MD, PhD**; Gómez-Garre, Dulcenombre PhD; Muñoz-Fernández, María A. MD, PhD*,††

JAIDS Journal of Acquired Immune Deficiency Syndromes: July 1st, 2014 - Volume 66 - Issue 3 - p 265–269
doi: 10.1097/QAI.0000000000000160
Brief Report: Basic and Translational Science

Abstract: We assessed high-density lipoprotein (HDL) anti-inflammatory properties in a cohort of vertically HIV-infected adolescents. We hypothesized that proatherogenic mechanisms related to inflammation and immune activation during HIV infection may impair HDL functionality and impact on the atherosclerotic burden. Compared with healthy controls, HDL from HIV-infected adolescents presented impaired functionality, as determined by its ability to inhibit monocyte chemotaxis in vitro, which correlated with detectable viral loads (P = 0.044), lower CD4 nadir (P = 0.043), increased levels of CD4 T-cell activation (P = 0.018), higher C-reactive protein (P = 0.009), and a tendency toward thicker carotid intima-media thickness (P = 0.071).

*Laboratorio de InmunoBiología Molecular, Department of Pediatrics, Instituto de Investigación Sanitaria Hospital General Universitario Gregorio Marañón (IiSGM), Servicio de Pediatría e Instituto de Investigación Sanitaria Hospital Gregorio Marañón, Madrid, Spain;

Laboratorio de Vascular, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain;

Department of Infectious Diseases, Servicio de Enfermedades Infecciosas e IRYCIS, Hospital Universitario Ramón y Cajal, and IRYCIS, Madrid, Spain;

§Department of Pediatrics, Servicio de Pediatría, Hospital General Universitario Gregorio Marañón, Madrid, Spain;

Department of Pediatrics, Unidad de Inmunodeficiencias pediátricas, Servicio de Pediatría, Hospital Universitario Doce de Octubre, Madrid, Spain;

Department of Pediatrics, Servicio de Pediatría, Hospital de Getafe, Madrid, Spain;

#Department of Pediatrics, Servicio de Pediatría, Hospital Carlos III, Madrid, Spain;

**Department of Internal Medicine, Servicio de Medicina Interna, Hospital Clínico San Carlos, Madrid, Spain; and

††Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.

Correspondence to: María A. Muñoz-Fernández, MD, PhD, Laboratorio de Inmunobiología Molecular, Hospital General Universitario Gregorio Marañón, C/Dr Esquerdo 46, Madrid 28007, Spain (e-mail:

Partial/final results of this study have been presented at the 31st Congress of the European Society of Pediatric Infectious Diseases, ESPID, June 2013, Milan, Italy (ref. A-792).

Partially supported by a Small Grant Award from the European Society of Pediatric Infectious Diseases (ESPID), Fondos de Investigación Sanitaria, ISCIII [grant: PI10/1009; PI12/01483) of the Spanish Ministry of Science and Innovation, and Red Española de Investigación en SIDA (RIS), [grants: RETIC RD06/0006/0035; RD12-0017-0037; RD06/0006/0021; RD12/0017/0029 and RD09/0076/00103]. T.S. and S.S.-V. are funded by grants from the Spanish Ministry of Health (Ayudas para Contratos de Formación en Investigación Río Hortega). L.D. is co-funded by the Spanish Ministry of Health.

The authors have no conflicts of interest to disclose.

Received April 03, 2014

Accepted April 03, 2014

© 2014 by Lippincott Williams & Wilkins