Measurement of the full repertoire of HIV-1 vaccine elicited epitope specificities (of different antibody isotypes/subclasses) both systemically and at mucosal sites enables a better understanding of the breadth and diversity of humoral responses that are possible with current vaccine candidates. The results from the RV144 correlates analysis have significantly informed our understanding of how to analytically probe the HIV-1 vaccine elicited antibody repertoire. Several leading hypotheses were generated that are critical to test in future HIV-1 vaccine candidates. Measurements of the response rates and magnitudes of V1V2 IgG antibodies and Env IgA binding antibodies elicited by different vaccine regimens (different vector, adjuvant and Env immunogen formulations) are important for understanding whether these correlates can be confirmed with other regimens. Additionally, non-neutralizing antibody functions (FcR mediated antiviral functions, virion capture etc.) and specificities, like gp41 antibodies, elicited by HIV-1 vaccines are important to profile and test for protective functions. Determining the diversity of responses by different HIV-1 vaccine regimens can help guide further immunogen design and vaccine strategies for specifically targeting the elicitation of protective antibodies.
© 2013 Lippincott Williams & Wilkins, Inc.