EPIDEMIOLOGY AND SOCIAL SCIENCE: PDF OnlyCoronary Heart Disease in HIV-Infected IndividualsCurrier, Judith S. MD, MSc*; Taylor, Anne MD†; Boyd, Felicity PhD, MPH‡; Dezii, Christopher M. RN, MBA§; Kawabata, Hugh MA§; Burtcel, Beth PharmD§; Maa, Jen-Fue PhD§; Hodder, Sally MD§ Author Information *David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, California; †University of Minnesota School of Medicine, Minneapolis, Minnesota; ‡Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; and §Bristol-Myers Squibb Company, Princeton New Jersey Address correspondence and reprint requests to Judith S. Currier, MD, MSc, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, BH-412, CHS Los Angeles, CA 90095. E-mail: [email protected]. Funded by the Bristol-Myers Squibb Company. Manuscript received April 14, 2003; accepted April 21, 2003. JAIDS Journal of Acquired Immune Deficiency Syndromes: August 1, 2003 - Volume 33 - Issue 4 - p 506-512 Free Abstract It is currently unknown whether there is an increased risk of coronary heart disease (CHD) in patients with HIV infection. In addition, the contribution of antiret-roviral therapy (ART) to CHD risk has not been quantified. We reviewed administrative claims data for HIV-infected and -uninfected individuals from the California Medicaid population and compared the incidence of and relative risk (RR) for CHD using log-linear regression analyses between groups. The association between exposure to ART and CHD incidence was also assessed. Of 3,083,209 individuals analyzed, 28,513 were HIV-infected. The incidence of CHD among young men (up to age 34) and women (up to age 44) with HIV infection was significantly higher than that among non-HIV-infected individuals. The covariate-adjusted RR for the development of CHD in individuals receiving ART compared with those not receiving ART was 2.06 (P < 0.001) in HIV-infected individuals aged 18-33 years. There were no statistically significant associations between ART exposure and CHD in other age groups. CHD incidence appears accelerated among young HIV-infected individuals. Strategies to reduce CHD risk should be incorporated into HIV primary care. © 2003 Lippincott Williams & Wilkins, Inc.