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HIV-2 Subtype Circulating in India (South)

Kannangai Rajesh; Shaji, Ramachandran V.; Ramalingam, Sandeep; Jesudason, Mary V.; Abraham, Oriapadickal C.; George, Renu; Shanmugam, Arvindh P.; Schwartz, David H.; Sridharan, Gopalan
JAIDS Journal of Acquired Immune Deficiency Syndromes: June 1st, 2003

Summary:The genetic types and subtypes of HIV vary from region to region. This study looked at the relative prevalence of HIV-2 subtypes in south India. Nucleotide sequencing of the HIV-2 envelope V3 region of strains from 11 individuals infected with HIV-2 and one individual who had dual infection with HIV-1 and HIV-2 was performed. Phylogenetic analysis showed that all individuals were infected with HIV-2 subtype A. These strains were from individuals who live in different regions of south India. In all, up to present, 17 strains inclusive of the authors' 12 have been sequenced, and subtype A of HIV-2 is seen in both monoinfections and dual infections with HIV-1 in India.

Address correspondence and reprint requests to Dr. G. Sridharan, Department of Clinical Virology, Christian Medical College Hospital, Vellore-632004, India. E-mail:

Manuscript received April 8, 2002; accepted January 21, 2003.

© 2003 Lippincott Williams & Wilkins, Inc.