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Biglione Mirna M.; Pizarro, Manuel; Puca, Alberto; Salomón, Horacio E.; Berría, Maria I.
JAIDS Journal of Acquired Immune Deficiency Syndromes: April 1st, 2003

Compared with other regions in Argentina, greater human T-cell lymphotropic virus type I (HTLV-I) seroprevalence has been reported in Jujuy Province, where it reaches 2.32% in the general population, so that a search for HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) cases deserved to be carried out. Accordingly, a clinically diagnosed and serologically confirmed cluster of cases in 1 man and 10 women, including 2 sisters, is described here. Most patients (9/11) were born in Cochinoca Department, located in an Andes highland area called Puna Jujeña, situated at more that 3400 m above sea level. No history of risk factors was disclosed, except for a single transfusion in 1 patient. In contrast to the Andean region of Bolivia, where high HTLV-I seroprevalence is in part attributable to Japanese immigrants, the Jujuy population mainly consists of aborigines, mestizos, and European descendants. Therefore, the long-term presence of virus in Jujuy natives may be taken for granted. Considering the HAM/TSP cluster described here plus previously reported isolated cases in neighboring Salta Province, we speculate that the Puna Jujeña region and regions in that vicinity would be a microepidemic focus of disease. To determine the role of possible pathogenic cofactors such as geographic, ethnic, genetic, and cultural features, further pertinent surveys are required in subtropical northwestern Argentina.

Address correspondence and reprint requests to Mirna Marcela Biglione, Centro Nacional de Referencia para el SIDA, Departamento de Microbiología, Piso 11, Facultad de Medicina, Universidad de Buenos Aires Paraguay 2155 Piso 11, (1121) Buenos Aires, Argentina; e-mail:

Manuscript received June 6, 2002; accepted November 13, 2002.

© 2003 Lippincott Williams & Wilkins, Inc.