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Furukawa Yoshitaka; Kubota, Ryuji; Eiraku, Nobutaka; Nakagawa, Masanori; Usuku, Koichiro; Izumo, Shuji; Osame, Mitsuhiro
JAIDS Journal of Acquired Immune Deficiency Syndromes: March 1st, 2003

Summary:Clinical and laboratory findings were examined for 111 human T-cell lymphotropic virus type I (HTLV-I)-infected blood donors. HTLV-I provirus loads in subjects with a family history of adult T-cell leukemia (ATL) or HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) tended to be higher than those in subjects without a family history of these conditions. There were 3 asymptomatic patients with ATL, 4 with a history of uveitis, 7 with hyperreflexia in the lower limbs, and 3 with urinary frequency in the night. The mean CD4 cell/CD8 cell ratio ± SD was significantly lower (p < .0001) in subjects with hyperreflexia in the lower limbs (1.3 ± 0.2) than in subjects without any clinical abnormalities (1.7 ± 0.6), suggesting that subjects with hyperreflexia in the lower limbs already have some immunologic abnormalities. The concordance of HTLV-I infection between husband and wife was lower in this study than in a previous study. HTLV-I-related inflammatory symptoms were more frequent (p = .021, Fisher exact test; OR = 9.5; 95% CI, 1.7-53.5) in HTLV-I tax A-infected donors (3 [50%] of 6 donors) than in HTLV-I tax B-infected donors (10 [9.5%] of 105 donors), suggesting different risks of HTLV-I-related symptoms according to the virus genotype.

Address correspondence and reprint requests to Dr. Yoshitaka Furukawa, Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan; e-mail:

Manuscript received January 4, 2001; accepted September 11, 2002.

© 2003 Lippincott Williams & Wilkins, Inc.