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Association of HIV-1 Viral Phenotype in the MT-2 Assay With Perinatal HIV Transmission

LaRussa Philip; Magder, Laurence S.; Pitt, Jane; Sill, Anne; Hillyer, George; Hollinger, Blaine F.; Lew, Judy; McIntosh, Kenneth; Kufera, Joseph; Bremer, Jim; Blattner, William; for the Women Infants Transmission Study
JAIDS Journal of Acquired Immune Deficiency Syndromes: May 1st, 2002
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A case-control design study was used to investigate the association of maternal HIV-1 phenotype in MT-2 cells at or near the time of delivery with perinatal transmission of HIV-1, controlling for maternal CD4 percentage and duration of rupture of membranes, in 48 transmitting and 96 nontransmitting HIV-1-infected mothers who gave birth between 1990 and 1995. The nonsyncytium-indueing (NSI) phenotype was more commonly seen in transmitting mothers compared with nontransmitting mothers (90% vs. 75%, p = .04). In a multivariable logistic regression model, the following maternal characteristics were significantly associated with HIV transmission: NSI phenotype (odds ratio [OR] = 6.08; 95% confidence interval [CI]: 1.73- 21.35) and log10 viral load (OR = 2.11; CI: 1.19-3.74). Finally, the association of NSI phenotype with transmission was stronger in transmitting women who received azidothymidine during pregnancy compared with transmitters who did not.

Address correspondence and reprint requests to Philip LaRussa, Division of Pediatric Infectious Diseases, Columbia University, College of Physicians and Surgeons, Room PH4 West-462, 622 West 168th Street, New York, NY 10032, U.S.A.;

Manuscript received August 17, 2001; accepted January 16, 2002.

© 2002 Lippincott Williams & Wilkins, Inc.