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Gérard Laurence; Agbalika, Félix; Sheldon, Julie; Maillard, Anne; Schulz, Thomas F.; Oksenhendler, Eric
JAIDS Journal of Acquired Immune Deficiency Syndromes: February 1st, 2001
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Summary:Human herpesvirus 8 (HHV-8) is closely associated with Kaposi's sarcoma (KS), HIV-associated Castleman's disease, and primary effusion lymphoma. As a high frequency of non-Hodgkin's lymphoma (NHL) has been reported in patients with HIV-associated KS, we hypothesized that HHV-8 infection could be indirectly implicated in the pathogenesis of NHL. We assessed the prevalence of HHV-8 antibodies in 63 patients with NHL compared with 126 HIV-infected matched control patients without NHL. Serum samples from cases and controls were assayed for antibodies to HHV-8 lytic and latent antigens using an indirect immunofluorescence assay. In patients with concordant serologic results, HHV-8 antibodies were detected in 41.5% of the NHL cases and 37% of the controls. This absence of a significant difference in HHV-8 seroprevalence between cases and controls (p = .73) does not support a possible role for HHV-8 infection in the development of NHL in HIV-infected patients.

Address correspondence and reprint requests to Laurence Gérard, Service d'Immuno-Hématologie, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75010, Paris, France; e-mail: laurence.gerard@

Manuscript received May 1, 2000; accepted October 31, 2000.

© 2001 Lippincott Williams & Wilkins, Inc.