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Humphrey Jean H.; Quinn, Thomas; Fine, David; Lederman, Howard; Yamini-Roodsari, Sedighe; Wu, Lee S. F.; Moeller, Suzen; Ruff, Andrea J.
Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology: January 1st, 1999

Summary:Vitamin A supplementation has been suggested for treatment and prevention of HIV infection. However, some in vitro data indicate that vitamin A may activate HIV. Randomly, 40 HIV-seropositive women of reproductive age were allocated to receive a single oral dose of 9900 μmol (300,000 IU) vitamin A or placebo. Plasma HIV-1 RNA concentration, total lymphocytes, selected lymphocyte subsets and activation markers, and in vitro lymphocyte proliferation to phytohemagglutinin (PHA) and Candida were measured before dosing and at various time points over an 8-week follow-up period. No differences were found between treatment groups in the frequency of signs or symptoms of acute vitamin A toxicity, nor were differences evident in any lymphocyte subset or activation marker at any time during follow-up. Mean and median viral load concentration at each time point and change in viral load from baseline to each follow-up point did not differ between treatment groups. No difference was measured between treatment groups in the proportion of women who responded to PHA or Candida. This study provides no evidence that high dose vitamin A supplementation of HIV-infected women is associated with significant clinical or immunologic adverse effects.

Address correspondence and reprint requests to Jean H. Humphrey, The Johns Hopkins School of Hygiene and Public Health, 615 North Wolfe Street, Room 2041, Baltimore, MD 21205, U.S.A.

Manuscript received September 11, 1997; accepted August 3, 1998.

© 1999 Lippincott Williams & Wilkins, Inc.