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Effect of Polyanionic Compounds on Intracutaneous and Intravaginal Herpesvirus Infection in Mice: Impact on the Search for Vaginal Microbicides with Anti-HIV Activity

Neyts J.; Clercq, E. De
JAIDS Journal of Acquired Immune Deficiency Syndromes: September 1995
Original Articles: PDF Only

Several polyanionic compounds were found to suppress intracutaneous infection of hairless mice with herpes simplex virus type 2 (HSV-2) only when present at the time of inoculation. Because (a) sexual intercourse is a major route of infection with human immunodeficiency virus (HIV); (b) due to the species-specificity of HIV, there is no small animal model to study intravaginal HIV infection; (c) HIV is equally or even more sensitive than HSV-2 to several polyanions; and (d) sulfated polymers may prevent the adhesion of (HIV-infected) lymphocytes to epithelial cells, we evaluated the effect of the compounds on intravaginal infection of mice with HSV-2. To this end, mice were infected intravaginally with a virus-compound mixture. Under the conditions used, the polysulfate dextran sulfate conferred only partial protection against infection and virus-induced mortality. However, PAVAS (a copolymer of acrylic acid with vinylalcohol sulfate) completely protected against the infection. These results should be taken into account when planning clinical studies with a vaginal polysulfate formulation for the prevention of sexually transmitted HIV and/or HSV-2 infections.

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