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Colebunders Robert L.; Lebughe, Izaley; Nzila, Nzilambi; Kalunga, Dikilu; Francis, Henry; Ryder, Robert; Piot, Peter
Journal of Acquired Immune Deficiency Syndromes: December 1989
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Cutaneous delayed-type hypersensitivity (DTH) reactions were assessed by the CMI-Multitest (Merieux, Lyon, France) in patients with different stages of human immunodeficiency virus (HIV) infection in Kinshasa, Zaire. Skin tests were read after 48–72 h. A reaction to an antigen was considered positive if there was induration of >2 mm. Cutaneous anergy occurred more often in HIV-seropositive patients than in healthy controls (p < 0.001) and was most prevalent in patients with advanced HIV illness. HIV-seropositive patients with a positive tuberculin reaction were more likely to have active tuberculosis (TB) than HIV-seropositive patients without a positive tuberculin reaction (p < 0.001). Therefore, a TB diagnosis should be pursued in HIV-seropositive patients with a positive tuberculin reaction.

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