Review: PDF OnlyHLA Antigen Frequencies in HIV-1 Seropositive Disease-Free Individuals and Patients with AIDSMann, Dean L.; Murray, Christine*; Yarchoan, Robert†; Blattner, William A.‡; Goedert, James J.‡Author Information †Laboratory of Human Carcinogenesis, Clinical Oncology Program, Rockville, Maryland ‡Laboratory of Human Carcinogenesis Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland *Laboratory of Human Carcinogenesis Environmental Epidemiology Branch Braton Biotech, Inc., Rockville, Maryland Journal of Acquired Immune Deficiency Syndromes: January 1988 - Volume 1 - Issue 1 - p 13-17 Free Abstract HLA-A, -B, -C, -DR, and -DQ antigen phenotypes were determined in 266 Caucasian homosexual men, 90 of whom were HIV-1 seronegative, 94 HIV-1 seropositive AIDS-free, and 82 with a diagnosis of AIDS [36 with Kaposi's sarcoma (KS), 34 with opportunistic infection (OI), and 12 with KS and OI]. No significant differences in HLA-A or -B antigen frequencies were found in any comparisons of these groups. However, in comparisons of seropositive AIDS-free men with the AIDS groups, HLA-Cw7 was increased in frequency in OI and HLA-DR1, -DRw 14, and -DQw 1 in KS. HLA-DR3 and -DQw3 frequencies were decreased in KS, and DRw53 was decreased in OI. In a cohort of 102 HIV seropositive individuals that were followed for a mean of 43 months, AIDS developed in HLA-DR 1 positive men more frequently than in individuals with other HLA-DR phenotypes (p = 0.02). These results demonstrate probable genetic differences between individuals developing KS and OI and indicate that the HLA-DR 1 phenotype is a risk factor in disease progression in human immunodeficiency virus (HlV)-infected individuals. © Lippincott-Raven Publishers.