Case ReportNegative-pressure pulmonary edema after laparoscopic appendectomyChang, Wei Chao PhD, DHSc, PA-C Author Information At the time this article was written, Wei Chao Chang practiced in the Department of Surgery at MedStar Good Samaritan Hospital in Baltimore, Md. He now practices in the Department of Surgery at Greater Baltimore Medical Center. The author has disclosed no potential conflicts of interest, financial or otherwise. Journal of the American Academy of Physician Assistants 32(8):p 28-30, August 2019. | DOI: 10.1097/01.JAA.0000574524.09174.bb Buy Metrics Abstract Negative-pressure pulmonary edema (NPPE) is acute-onset bilateral pulmonary interstitial edema. This condition can be caused by significant negative intrathoracic pressure generated by large inspiratory effort against acute upper airway obstruction. Postoperative NPPE is rare but potentially life-threatening if not recognized and treated promptly. This article describes a patient who developed postoperative NPPE following a laparoscopic appendectomy. Copyright © 2019 American Academy of Physician Assistants