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Clinical utility of next-generation sequencing in precision oncology

Hux, Anna, MMS, PA-C; Lewis, Amanda, MMS, PA-C; Sachwitz, Drew, MMS, PA-C; Gregory, Tanya, PhD

Journal of the American Academy of PAs: January 2019 - Volume 32 - Issue 1 - p 35–39
doi: 10.1097/01.JAA.0000550287.71026.23
Review Article

ABSTRACT The Precision Medicine Initiative (PMI) aims to change the way diseases are diagnosed and treated by taking into account a patient's genome, lifestyle, and environment. This type of research also uncovers potential biomarkers that can lead to the development of novel targeted therapies. Next-generation sequencing (NGS) is a new technology that facilitates collection of this genetic information by processing large amounts of DNA in an efficient and cost-effective way. NGS is particularly useful in oncology and has already begun to transform cancer management.

At the time this article was written, Anna Hux, Amanda Lewis, and Drew Sachwitz were students in the PA program at Wake Forest School of Medicine in Winston-Salem, N.C. Ms. Hux now practices hematology/oncology at Vanderbilt University Medical Center in Nashville, Tenn. Ms. Lewis now practices in the ED at Chippenham Hospital in Richmond, Va. Mr. Sachwitz practices in the orthopedic department at Highland Hospital in Oakland, Calif. Tanya Gregory is an assistant professor and director of student services in the Department of PA Studies at Wake Forest. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Copyright © 2019 American Academy of Physician Assistants
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