More than 300,000 Americans suffer a cardiac arrest outside of the hospital each year and even among those who are successfully resuscitated and survive to hospital admission, outcomes remain poor. Temperature management (previously known as therapeutic hypothermia) is the only intervention that has been reproducibly demonstrated to ameliorate the neurologic injury that follows cardiac arrest. The results of a recent large randomized controlled trial have highlighted the uncertainty about temperature management strategies following cardiac arrest. This article reviews the issues and recommendations.
Patrick J. Coppler is an advanced practice provider resident in the Department of Critical Care Medicine at the University of Pittsburgh. Cameron Dezfulian is an assistant professor of critical care medicine at the University of Pittsburgh. Jonathan Elmer is an assistant professor of emergency medicine and critical care medicine at the University of Pittsburgh. Jon C. Rittenberger is an associate professor of emergency medicine, occupational therapy, and clinical and translational science at the University of Pittsburgh. Mr. Coppler received funding from the Pittsburgh Emergency Medical Foundation. Drs. Dezfulian and Elmer disclose that their research time is supported by grants from the NINDS and National Heart, Lung, and Blood Institute, respectively. The authors have disclosed no other potential conflicts of interest, financial or otherwise.
The Post Cardiac Arrest researchers, all of the University of Pittsburgh, are Dr. Rittenberger; Clifton W. Callaway, MD, PhD, professor of emergency medicine; Francis X. Guyette, MD, MPH, associate professor of emergency medicine; Ankur A. Doshi, MD, assistant professor of emergency medicine; Dr. Dezfulian; Dr. Elmer; Bradley J. Molyneaux, MD, PhD, assistant professor of critical care medicine; and Lillian Emlet, MD, MS, assistant professor of critical care medicine.