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Does low-dose methotrexate deserve more respect from clinicians?

Luu, Brent, PharmD, BCPS, BCACP; Rodway, George W., PhD, APRN

Journal of the American Academy of PAs: May 2017 - Volume 30 - Issue 5 - p 12–15
doi: 10.1097/01.JAA.0000515554.91731.82
Pharmacology Consult

ABSTRACT Medical errors associated with low-dose methotrexate may be life-threatening. Prescribers should be cognizant of the medication's toxicities and the persistent challenges in preventing adverse events. This article reviews the properties of methotrexate and its common drug-drug interactions. Best practices from the Institute for Safe Medication Practices, aimed at reducing methotrexate errors, are highlighted.

At the University of California, Davis, School of Nursing in Sacramento, Calif., Brent Luu is an assistant clinical professor of nursing and George W. Rodway is an associate professor of clinical nursing. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Mary Lou Brubaker, PharmD, PA-C, department editor

Copyright © 2017 American Academy of Physician Assistants
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