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Which antidotes are available for the novel oral anticoagulants?

Thomas, Rebekah PharmD, PA-C, BCPS, BC-ADM; Gonzalez, Renzo

Journal of the American Academy of PAs: July 2016 - Volume 29 - Issue 7 - p 12–13
doi: 10.1097/01.JAA.0000484309.11932.5e
Pharmacology Consult

ABSTRACT Use of novel (or target-specific) oral anticoagulants continues to increase. This article reviews idarucizumab and andexanet alfa, two antidotes that can be used to reverse anticoagulation in patients needing emergency surgery or with life-threatening bleeding.

Rebekah Thomas is an assistant professor in the PA program at Philadelphia College of Osteopathic Medicine's Georgia campus in Suwanee, Ga. Renzo Gonzalez is a student in the doctor of pharmacy program at Philadelphia College of Osteopathic Medicine. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Mary Lou Brubaker, PharmD, PA-C, department editor

Copyright © 2016 American Academy of Physician Assistants
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