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HIV pharmacotherapy: A review of integrase inhibitors

Wong, Elaine PharmD, BCPS; Trustman, Nathan; Yalong, April

Journal of the American Academy of PAs: February 2016 - Volume 29 - Issue 2 - p 36–40
doi: 10.1097/01.JAA.0000475465.07971.19
Review Article

ABSTRACT Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral agents used to treat HIV. These drugs—raltegravir, elvitegravir, and dolutegravir—are preferred options for treatment-naïve patients when used in combination with two nucleoside reverse transcriptase inhibitors. Based on clinical trials, INSTIs have been proven to be effective with minimal safety concerns. This article reviews the pharmacologic profile, role in therapy, and safety and efficacy of each agent.

Elaine Wong is an associate professor of pharmacy practice at Long Island University's Arnold & Marie Schwartz College of Pharmacy and Health Sciences (LIU Pharmacy) in Brooklyn, N.Y. At the time this article was written, Nathan Trustman and April Yalong were students in the doctor of pharmacy program at LIU Pharmacy. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Copyright © 2016 American Academy of Physician Assistants
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