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Is combination therapy appropriate for hypothyroidism?

Linder, Lauren MacLeod PharmD; Clements, Jennifer N. PharmD, BCPS, CDE, BCACP

Journal of the American Academy of PAs: September 2015 - Volume 28 - Issue 9 - p 16–19
doi: 10.1097/01.JAA.0000470438.14941.98
Pharmacology Consult

ABSTRACT Levothyroxine is the first-line drug for treating hypothyroidism. This article reviews the literature on combination therapy using levothyroxine and liothyronine, and found that only one study produced beneficial outcomes; other studies reported increased adverse reactions among participants. Levothyroxine should remain the drug of choice for hypothyroidism. Adequate trials with homogenous populations and large sample sizes are needed to determine whether combination therapy can be recommended for patients with hypothyroidism.

Lauren MacLeod Linder is a recent graduate of the doctor of pharmacy program at Presbyterian College School of Pharmacy in Clinton, S.C. Jennifer N. Clements is chair and an associate professor in the Department of Pharmacy Practice at Presbyterian College School of Pharmacy. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Mary Lou Brubaker, PharmD, PA-C, department editor

Copyright © 2015 American Academy of Physician Assistants
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