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Are antidepressants safe in the first trimester of pregnancy?

Shealy, Kayce M. PharmD, BCPS, BCACP, CDE

Journal of the American Academy of PAs: April 2015 - Volume 28 - Issue 4 - p 16–17
doi: 10.1097/01.JAA.0000460911.55472.76
Pharmacology Consult

Antidepressants have been linked to cardiac malformations when used early in pregnancy, particularly the first trimester. However, recent analyses suggest that the overall risk of malformations is very low. When determining appropriate therapy for pregnant women or women who plan to become pregnant, providers should consider the growing body of evidence compared with the potential harm caused if maternal medical conditions are not treated.

Kayce M. Shealy is an assistant professor of pharmacy practice at Presbyterian College School of Pharmacy in Clinton, S.C. The author has disclosed no potential conflicts of interest, financial or otherwise.

Mary Lou Brubaker, PharmD, PA-C, department editor

Copyright © 2015 American Academy of Physician Assistants
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