Open this free special issue for reports on a multidisciplinary research conference, Strategies to Improve Total Knee Arthroplasty(TKA), which focused on approaches to improve TKA outcomes. The conference brought together clinicians, scientists, and other important stakeholders to exchange ideas and develop strategies to improve the outcomes of TKA. The aim was to formulate questions directed to determine how well to prevent or manage complications and thus improve outcomes and satisfaction for patients who choose arthroplasty to treat their severe knee arthritis or injury. Start reading this issue now to get a recent review of the state of TKA and strategies for improving outcomes.