Reviews: Review ArticleHead-Neck Taper Corrosion in Metal-on-Polyethylene Total Hip Arthroplasty: Risk Factors, Clinical Evaluation, and Treatment of Adverse Local Tissue ReactionsFitz, David MD; Klemt, Christian PhD; Chen, Wenhao MD; Xiong, Liang MD; Yeo, Ingwon MD; Kwon, Young-Min MD, PhDAuthor Information From the Department of Orthopaedic Surgery, Bioengineering Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA. None of the following authors or any immediate family member has received anything of value from or has stock or stock options held in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Fitz, Dr. Klemt, Dr. Chen, Dr. Xiong, Dr. Yeo, and Dr. Kwon. Journal of the American Academy of Orthopaedic Surgeons: November 15, 2020 - Volume 28 - Issue 22 - p 907-913 doi: 10.5435/JAAOS-D-20-00475 Metrics Abstract Adverse local tissue reaction (ALTR) associated with mechanically assisted crevice corrosion of metal-on-polyethylene (MoP) head-neck modular total hip arthroplasty (THA), similarly observed in the metal-on-metal bearing, is a growing concern in MoP THA patients. Given the complex pathogenesis as well as variable clinical presentation, the diagnosis can be challenging. This article focuses on providing surgeons with an evidence-based update on (1) implant, surgical, and patient risk factors associated with ALTRs; (2) clinical systematic evaluation; and (3) surgical management options for ALTRs in MoP THA patients based on the currently available evidence. Copyright 2020 by the American Academy of Orthopaedic Surgeons.