Reviews: Review ArticleCartilage Injury in the Knee: Assessment and Treatment OptionsKrych, Aaron J. MD; Saris, Daniel B. F. MD, PhD; Stuart, Michael J. MD; Hacken, Brittney MDAuthor Information From the Department of Orthopedic Surgery and Sports Medicine, Mayo Clinic, Rochester, MN. None of the following authors or any immediate family member has received anything of value from or has stock or stock options held in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Krych, Dr. Saris, Dr. Stuart, and Dr. Hacken. Journal of the American Academy of Orthopaedic Surgeons: November 15, 2020 - Volume 28 - Issue 22 - p 914-922 doi: 10.5435/JAAOS-D-20-00266 Take the CME Test Metrics Abstract Cartilage injuries in the knee are common and can occur in isolation or in combination with limb malalignment, meniscus, ligament, and bone deficiencies. Each of these problems must be addressed to achieve a successful outcome for any cartilage restoration procedure. If nonsurgical management fails, surgical treatment is largely based on the size and location of the cartilage defect. Preservation of the patient's native cartilage is preferred if an osteochondral fragment can be salvaged. Chondroplasty and osteochondral autograft transfer are typically used to treat small (<2 cm2) cartilage defects. Microfracture has not been shown to be superior to chondroplasty alone and has potential adverse effects, including cyst and intralesional osteophyte formation. Osteochondral allograft transfer and matrix-induced autologous chondrocyte implantation are often used for larger cartilage defects. Particulated juvenile allograft cartilage is another treatment option for cartilage lesions that has good to excellent short-term results but long-term outcomes are lacking. Copyright 2020 by the American Academy of Orthopaedic Surgeons.