Reviews: Orthopaedic AdvancesCurrent Evidence-based Indications for Modern Noncemented Total Knee ArthroplastyChristensen, David D. MD; Klement, Mitchell R. MD; Moschetti, Wayne E. MD, MS; Fillingham, Yale A. MDAuthor Information From the Orthopedic Specialist of Seattle, Seattle, WA (Dr. Christensen), the Orthopaedic Associates of Wisconsin, Pewaukee, WI (Dr. Klement), and the Department of Orthopaedic Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH (Dr. Moschetti, and Dr. Fillingham). Dr. Christensen or an immediate family member has received research or institutional support from Stryker and OREF. Dr. Moschetti or an immediate family member serves as a paid consultant to Johnson & Johnson; is a member of a speakers' bureau or has made paid presentations on behalf of Johnson & Johnson and Medcape; has received research or institutional support from Johnson & Johnson; has received nonincome support (such as equipment or services), commercially derived honoraria, or other nonresearch–related funding (such as paid travel) from Medacta; and serves as a board member, owner, officer, or committee member of New England Orthopaedic Society. Dr. Fillingham or an immediate family member has received IP royalties from Medacta; serves as a paid consultant to Johnson & Johnson and Medacta; has stock or stock options held in Muvr Labs, Parvizi Surgical Innovations; serves as a board member, owner, officer, or committee member of AAOS, and AAHKS. Neither Dr. Klement nor any immediate family member has received anything of value from or has stock or stock options held in a commercial company or institution related directly or indirectly to the subject of this article. Journal of the American Academy of Orthopaedic Surgeons: October 15, 2020 - Volume 28 - Issue 20 - p 823-829 doi: 10.5435/JAAOS-D-20-00435 Metrics Abstract Total knee arthroplasty (TKA) is one of the most common procedures performed in orthopaedic surgery. Traditionally, most TKAs have been performed by cementing the implant to the bone with polymethyl methacrylate to provide fixation. Noncemented implants that rely on boney ingrowth for fixation are increasingly appealing to surgeons, given success in total hip arthroplasty and the desire for long-term stability of implants in younger patients. Despite high failure rates with early designs, several series of recent designs have demonstrated improved survivorship, although this has not been confirmed in larger registry studies. Modern screwless designs with improved porous coating are thought to contribute to better ingrowth and have been designed to address previous implant pitfalls. Surgeons must be aware of the potential advantages and limitations of noncemented TKA. Copyright 2020 by the American Academy of Orthopaedic Surgeons.