Review ArticleMedicinal Cannabis in Orthopaedic PracticeKleeman-Forsthuber, Lindsay T. MD; Dennis, Douglas A. MD; Jennings, Jason M. MD, DPTAuthor Information From the Porter Adventist Hospital, Denver, CO (Dr. Kleeman-Forsthuber, Dr. Dennis, and Dr. Jennings), the Department of Mechanical and Materials Engineering, Denver University, Denver, CO (Dr. Dennis and Dr. Jennings), the Department of Orthopaedics, University of Colorado School of Medicine, Denver, CO (Dr. Dennis), and the Department of Biomedical Engineering, University of Tennessee, Knoxville, TN (Dr. Dennis). None of the following authors or any immediate family member has received anything of value from or has stock or stock options held in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Kleeman-Forsthuber, Dr. Dennis, and Dr. Jennings. Journal of the American Academy of Orthopaedic Surgeons: April 1, 2020 - Volume 28 - Issue 7 - p 268-277 doi: 10.5435/JAAOS-D-19-00438 Metrics Abstract Cannabis has gained widespread public advocacy since its legalization in several states with recent evidence suggesting that its self-reported use has increased in patients undergoing a primary total joint arthroplasty. The endocannabinoid system has been proposed to play a role in decreasing the inflammatory cascade and enhancing pain management. For these reasons, interest has emerged in the orthopaedic community as a potential treatment or adjunct to treatment in many musculoskeletal conditions. However, the evidence to date is scant and precludes recommendations for its widespread use. Given the current paucity of evidence in the orthopaedic cohort, future research is warranted in this area to determine the efficacy and safety before endorsements can be made by orthopaedic surgeons. Copyright 2019 by the American Academy of Orthopaedic Surgeons.