Review ArticleNecrotizing Infections of the Hand and Wrist: Diagnosis and Treatment OptionsChoueka, Jack MD; De Tolla, Jadie E. MDAuthor Information From the Department of Orthopaedic Surgery, Maimonides Medical Center, Brooklyn, NY. None of the following authors or any immediate family member has received anything of value from or has stock or stock options held in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Choueka and Dr. De Tolla. Journal of the American Academy of Orthopaedic Surgeons: January 15, 2020 - Volume 28 - Issue 2 - p e55-e63 doi: 10.5435/JAAOS-D-17-00716 Metrics Abstract Necrotizing infections of the hand and wrist are important clinical entities because of their rapidly progressive and potentially lethal nature. These infections encompass a spectrum of diseases with overlapping signs and symptoms, which can be subtle and nonspecific. If the brief prodromal period of these infections goes unrecognized, a local area of devitalized tissue can evolve into fulminant infection, multiorgan failure, and potentially death. Early recognition and treatment including administration of broad-spectrum antibiotics and surgical débridement are paramount to improving patient outcomes. Copyright 2019 by the American Academy of Orthopaedic Surgeons.