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Cutibacterium acnes in Spine Pathology

Pathophysiology, Diagnosis, and Management

Khalil, Jad G. MD; Gandhi, Sapan D. MD; Park, Daniel K. MD; Fischgrund, Jeffrey S. MD

JAAOS - Journal of the American Academy of Orthopaedic Surgeons: July 15, 2019 - Volume 27 - Issue 14 - p e633–e640
doi: 10.5435/JAAOS-D-17-00698
Review Article

Cutibacterium acnes, long thought to be skin flora of pathological insignificance, has seen a surge in interest for its role in spine pathology. C acnes has been identified as a pathogen in native spine infection and osteomyelitis, which has implications in the management compared with more commonly recognized pathogens. In addition, It has also been recognized as a pathogen in postoperative and implant-associated infections. Some evidence exists pointing to C acnes as an unrecognized source of otherwise aseptic pseudarthrosis. Recently, it is hypothesized that low virulent organisms, in particular C acnes, may play a role in degenerative disk disease and the development of Modic end plate changes found in MRI. To this end, controversial implications exist in terms of the use of antibiotics to treat certain patients in the setting of degenerative disk disease. C acnes continues to remain an expanding area of interest in spine pathology, with important implications for the treating spine surgeon.

From the Department of Orthopaedics, Beaumont Health System, Royal Oak, MI.

None of the following authors or any immediate family member has received anything of value from or has stock or stock options held in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Khalil, Dr. Gandhi, Dr. Park, and Dr. Fischgrund.

© 2019 by American Academy of Orthopaedic Surgeons
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