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Sex-specific Outcomes and Predictors of Concussion Recovery

Davis-Hayes, Cecilia BA; Gossett, James D. ATC; Levine, William N. MD; Shams, Tanzid MD; Harada, Jumpei MS, ATC; Mitnick, Jeremy BS; Noble, James MD

JAAOS - Journal of the American Academy of Orthopaedic Surgeons: December 2017 - Volume 25 - Issue 12 - p 818–828
doi: 10.5435/JAAOS-D-17-00276
Research Article
SDC

Introduction: Sports-related concussion (SRC) is a substantial concern in collegiate athletics. Some studies of SRC that make comparisons by sex are limited by sample size, follow-up duration, or referral bias. Sex-specific predictors of occurrence and recovery are uncertain.

Methods: A 15-year retrospective cohort study identified 1,200 Columbia University varsity athletes (822 male [68.5%], 378 female [31.5%]) at risk of collegiate SRC.

Results: A total of 228 athletes experienced at least one collegiate concussion, including 88 female athletes (23.3% of female athletes) and 140 male athletes (17.0% of male athletes) (P = 0.01); follow-up data were available on 97.8% of these athletes. Postconcussion symptoms were similar by sex, with the exception of sleep disturbance (29.3% of male athletes versus 42.0% of female athletes; P = 0.048) and memory impairment (43.6% of male athletes versus 30.7% of female athletes; P = 0.052), although the latter difference was not statistically significant. Risk factors for collegiate concussion included female sex (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.1 to 2.0) or precollegiate concussion (OR, 2.9; 95% CI, 2.2 to 3.9). Prolonged recovery was predicted by the presence of eight or more postconcussion symptoms for all athletes (OR, 3.77; 95% CI, 1.68 to 8.46) and for female athletes only (OR, 8.24; 95% CI, 1.58 to 43.0); this finding was not statistically significant for male athletes.

Discussion: Female athletes were more likely than male athletes to experience concussion. Increasing numbers of prior concussions predicted recurrence. Although most postconcussion symptoms were highly intercorrelated, the total number of symptoms predicted a prolonged recovery period.

Conclusion: This study confirms sex-based differences in SRCs. Longitudinal studies of collegiate cohorts should attempt to limit follow-up bias and offer opportunities to clarify determinants of SRC.

From the College of Physicians and Surgeons (Ms. Davis-Hayes), Columbia Athletics (Mr. Gossett and Mr. Harada), the Department of Orthopaedics (Dr. Levine), the Department of Neurology, the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, and the Gertrude H. Sergievsky Center (Dr. Noble), Columbia University, New York, NY; the Department of Neurology, East Tennessee State University Quillen College of Medicine, Johnson City, TN (Dr. Shams); and the Department of Neuroscience, University of Michigan, Ann Arbor, MI (Mr. Mitnick).

Mr. Gossett or an immediate family member has stock or stock options held in Johnson & Johnson and serves as a board member, owner, officer, or committee member of the National Athletic Trainers’ Association. Dr. Levine or an immediate family member serves as an unpaid consultant to Zimmer Biomet. None of the following authors or any immediate family member has received anything of value from or has stock or stock options held in a commercial company or institution related directly or indirectly to the subject of this article: Ms. Davis-Hayes, Dr. Shams, Mr. Harada, Mr. Mitnick, and Dr. Noble.

Received April 11, 2017

Accepted August 23, 2017

© 2017 by American Academy of Orthopaedic Surgeons
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