Background and purpose: Chronic idiopathic constipation
(CIC) is a prevalent disorder affecting productivity, quality of life, and health care resource utilization. Nurse practitioners (NPs) play a critical function in managing patients presenting with CIC, with roles including evaluation, diagnosis, treatment decisions, and patient education. For adults with inadequate response or tolerability issues using over-the-counter treatments, three prescription agents (plecanatide
, linaclotide, and lubiprostone) are available in the United States to treat CIC, of which plecanatide
was mostly recently approved. This review provides NPs with a current overview and summary of plecanatide
in the current treatment landscape
PubMed was searched for the literature regarding clinical practice guidelines and published trial data for lubiprostone, linaclotide, and plecanatide
Efficacy and safety comparisons between prescription agents are limited beacause of the differences in trial duration and primary end points (all different). Generally, plecanatide
and linaclotide demonstrated similar efficacy, with plecanatide
demonstrating lower rates of adverse events.
Implications for practice:
The success of CIC treatment can be affected by patient adherence to the regimen, which is dependent on the efficacy and tolerability of treatment. Plecanatide
is a promising option for patients whose CIC symptoms are not adequately controlled using their current treatment approach.