September 2018: Val M. Runge, MD, a note from the Editor
This issue of the journal, as always, has many outstanding articles, representing cutting edge research in diagnostic imaging. More specifically, it is the first of two focused special issues concerning contrast media in diagnostic imaging. This issue deals only with MR and the gadolinium chelates. The first article
is a critically important review article, discussing the main methodological aspects needed for accurate design and translation of preclinical studies, reflecting upon quality issues in articles published recently elsewhere in the literature. Seven articles follow, including several excellent animal studies and three clinical assessments. Topics include important clarification of the specific localization of Gd deposits in the brain, the route of entry into the brain, an intricate study providing further evidence of the safety of the macrocyclic gadolinium chelates (demonstrating no dentate nucleus accumulation following intrathecal injection), an important study concerning breakthrough reactions with gadobenate dimeglumine, and an excellent review of NSF cases and incidence, providing new insight into this disease and emphasizing the important of objective parameters including structure, stability, pharmacokinetics, and dose.