This issue of the journal, as always, has many outstanding articles, representing cutting edge research in diagnostic imaging. More specifically, it is the first of two focused special issues concerning contrast media in diagnostic imaging. This issue deals only with MR and the gadolinium chelates. The first article is a critically important review article, discussing the main methodological aspects needed for accurate design and translation of preclinical studies, reflecting upon quality issues in articles published recently elsewhere in the literature. Seven articles follow, including several excellent animal studies and three clinical assessments. Topics include important clarification of the specific localization of Gd deposits in the brain, the route of entry into the brain, an intricate study providing further evidence of the safety of the macrocyclic gadolinium chelates (demonstrating no dentate nucleus accumulation following intrathecal injection), an important study concerning breakthrough reactions with gadobenate dimeglumine, and an excellent review of NSF cases and incidence, providing new insight into this disease and emphasizing the important of objective parameters including structure, stability, pharmacokinetics, and dose.​

Current Issue Highlights

Methodological Aspects for Preclinical Evaluation of Gadolinium Presence in Brain Tissue: Critical Appraisal and Suggestions for Harmonization—A Joint Initiative

Robert, Philippe; Frenzel, Thomas; Factor, Cécile; More

Investigative Radiology. 53(9):499-517, September 2018.

Multimodal Imaging Study of Gadolinium Presence in Rat Cerebellum: Differences Between Gd Chelates, Presence in the Virchow-Robin Space, Association With Lipofuscin, and Hypotheses About Distribution Pathway

Rasschaert, Marlène; Schroeder, Josef A.; Wu, Ting-Di; More

Investigative Radiology. 53(9):518-528, September 2018.

Modeling Gadoxetate Liver Uptake and Efflux Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging Enables Preclinical Quantification of Transporter Drug-Drug Interactions

Georgiou, Leonidas; Penny, Jeffrey; Nicholls, Glynis; More

Investigative Radiology. 53(9):563-570, September 2018.