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This issue of the journal, as always, has many outstanding articles, representing cutting edge research and technology in diagnostic imaging. Two articles further investigate gadolinium retention following linear GBCA administration, providing critical findings regarding patient age and chelation therapy, with the importance of pediatric research emphasized by the accompanying editorial. Papers featuring MR advances constitute the bulk of the February issue. Highlights include demonstration of further applicability of MR elastography (in lupus nephritis), the use of T1 mapping for grading renal cell carcinoma, showcasing gadoxetic acid-enhanced 3D MRC with iterative denoising for evaluation of the biliary tree in living liver donors, and the demonstration that machine learning with multiparametric MR of the breast enables early prediction of response to chemotherapy as well as survival outcomes. Although the majority of articles in this issue focus on MR, an important CT article highlights the use of a new technique (frequency selective non-linear blending) to improve substantially detection of brain metastases by this modality. An additional excellent article highlights the clinical utility of synthetic 2D mammography.

Current Issue Highlights

Does Age Interfere With Gadolinium Toxicity and Presence in Brain and Bone Tissues?: A Comparative Gadoterate Versus Gadodiamide Study in Juvenile and Adult Rats

Fretellier, Nathalie; Granottier, Agnès; Rasschaert, Marlène; More

Investigative Radiology. 54(2):61-71, February 2019.

Clinical Feasibility of Gadoxetic Acid–Enhanced Isotropic High-Resolution 3-Dimensional Magnetic Resonance Cholangiography Using an Iterative Denoising Algorithm for Evaluation of the Biliary Anatomy of Living Liver Donors

Kang, Hyo-Jin; Lee, Jeong Min; Ahn, Su Joa; More

Investigative Radiology. 54(2):103-109, February 2019.

Impact of Machine Learning With Multiparametric Magnetic Resonance Imaging of the Breast for Early Prediction of Response to Neoadjuvant Chemotherapy and Survival Outcomes in Breast Cancer Patients

Tahmassebi, Amirhessam; Wengert, Georg J.; Helbich, Thomas H.; More

Investigative Radiology. 54(2):110-117, February 2019.