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Acceleration of Magnetic Resonance Cholangiopancreatography Using Compressed Sensing at 1.5 and 3 T

A Clinical Feasibility Study

Taron, Jana, MD*; Weiss, Jakob, MD*; Notohamiprodjo, Mike, MD*; Kuestner, Thomas, PhD; Bamberg, Fabian, MD*; Weiland, Elisabeth, PhD; Kuehn, Bernd, PhD; Martirosian, Petros, PhD§

doi: 10.1097/RLI.0000000000000489
Original Articles

Objectives Magnetic resonance cholangiopancreatography (MRCP) is an established technique in routine magnetic resonance examination. By applying the compressed sensing (CS) acceleration technique to conventional MRCP sequences, scan time can be markedly reduced. With promising results at 3 T, there is a necessity to evaluate the performance at 1.5 T due to wide scanner availabilities. Aim of this study is to test the feasibility of accelerated 3-dimensional (3D) MRCP with extended sampling perfection with application-optimized contrasts using different flip angle evolution (SPACE) using CS in navigator triggering and in a single breath-hold in a clinical setting at 1.5 T and 3 T and compare it with a conventional navigator-triggered 3D SPACE-MRCP.

Materials and Methods Phantom measurements were performed to adapt sequence parameters. Conventional 3D SPACE-MRCP in navigator triggering (STD_MRCP) as well as CS-accelerated 3D SPACE-MRCP acquired in navigator triggering and in a single breath-hold (CS_MRCP and CS_BH_MRCP) was performed in 66 patients undergoing clinically induced MRI of the pancreatobiliary system at 1.5 T and 3 T. Image quality evaluation was performed by 2 independent radiologists. Dedicated statistics were performed (P < 0.05 considered significant).

Results In patient imaging, CS_MRCP was superior to STD_MRCP and CS_BH_MRCP in aspects of overall image quality at 1.5 T (P = 0.01; P < 0.001) and 3 T (P = 0.002; P = 0.013). Overall image quality in CS_BH_MRCP was inferior compared with STD_MRCP and CS_MRCP at 1.5 T. At 3 T, overall image quality in CS_BH_MRCP was superior to STD_MRCP (P = 0.001). Scan time was reduced by 25% to 46% covering 5% of k-space (CS_MRCP at 1.5 and 3 T) and 97% covering 3.6% of k-space (CS_BH_MRCP at 1.5 and 3 T).

Conclusions Compressed sensing-accelerated MRCP is feasible in clinical routine at 1.5 and 3 T offering major reduction of acquisition time. When applying a single breath-hold CS imaging, field strengths of 3 T are recommended.

From the *Department of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Tuebingen;

Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart;

Siemens Healthcare GmbH, Erlangen; and

§Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Tuebingen, Germany.

Received for publication March 6, 2018; and accepted for publication, after revision, April 26, 2018.

Conflicts of interest and sources of funding: none declared.

Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.investigativeradiology.com).

Correspondence to: Jana Taron, MD, Department of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3 72076 Tuebingen, Germany. E-mail: jana.taron@med.uni-tuebingen.de.

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