Review ArticlesMagnetic Resonance Imaging and Computed Tomography of the Brain—50 Years of Innovation, With a Focus on the FutureRunge, Val M. MD*; Aoki, Shigeki MD†; Bradley, William G. Jr MD, PhD‡; Chang, Kee-Hyun MD§; Essig, Marco MD∥; Ma, Lin MD, PhD¶; Ross, Jeffrey S. MD#; Valavanis, Anton MD**Author Information From the *Clinic for Neuroradiology, Institute for Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland; †Department of Radiology, Juntendo University, Tokyo, Japan; ‡Department of Radiology, University of California San Diego Health System, San Diego, CA; §Department of Radiology, Soonchunhyang University Hospital, Bucheon, Republic of Korea; ∥Department of Radiology, University of Manitoba, Winnipeg, Manitoba, Canada; ¶Department of Radiology, PLA General Hospital, Beijing, China; #Department of Neuroradiology, Barrow Neurological Institute, Phoenix, AZ; and **Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland. Received for publication February 6, 2015; and accepted for publication, after revision, March 24, 2015. Conflicts of interest and sources of funding: none declared. Correspondence to: Val M. Runge, MD, Clinic for Neuroradiology, Institute for Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland 8091. E-mail: firstname.lastname@example.org. Investigative Radiology: September 2015 - Volume 50 - Issue 9 - p 551-556 doi: 10.1097/RLI.0000000000000170 Buy Metrics Abstract This review focuses specifically on the developments in brain imaging, as opposed to the spine, and specifically conventional, clinical, cross-sectional imaging, looking primarily at advances in magnetic resonance imaging (MRI) and computed tomography (CT). These fields are viewed from a perspective of landmark publications in the last 50 years and subsequently more in depth using sentinel publications from the last 5 years. It is also written from a personal perspective, with the authors having witnessed the evolution of both fields from their initial clinical introduction to their current state. Both CT and MRI have made tremendous advances during this time, regarding not only sensitivity and spatial resolution, but also in terms of the speed of image acquisition. Advances in CT in recent years have focused in part on reduced radiation dose, an important topic for the years to come. Magnetic resonance imaging has seen the development of a plethora of scan techniques, with marked superiority to CT in terms of tissue contrast due to the many parameters that can be assessed, and their intrinsic sensitivity. Future advances in MRI for clinical practice will likely focus both on new acquisition techniques that offer advances in speed and resolution, for example, simultaneous multislice imaging and data sparsity, and on standardization and further automation of image acquisition and analysis. Functional imaging techniques including specifically perfusion and functional magnetic resonance imaging will be further integrated into the workflow to provide pathophysiologic information that influence differential diagnosis, assist treatment decision and planning, and identify and follow treatment-related changes. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.