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Phase-Sensitive Dual-Inversion Recovery for Accelerated Carotid Vessel Wall Imaging

Bonanno, Gabriele MSc; Brotman, David BSc; Stuber, Matthias PhD

doi: 10.1097/RLI.0000000000000110
Original Article

Objectives Dual-inversion recovery (DIR) is widely used for magnetic resonance vessel wall imaging. However, optimal contrast may be difficult to obtain and is subject to RR variability. Furthermore, DIR imaging is time-inefficient and multislice acquisitions may lead to prolonged scanning times. Therefore, an extension of phase-sensitive (PS) DIR is proposed for carotid vessel wall imaging.

Methods The statistical distribution of the phase signal after DIR is probed to segment carotid lumens and suppress their residual blood signal. The proposed PS-DIR technique was characterized over a broad range of inversion times. Multislice imaging was then implemented by interleaving the acquisition of 3 slices after DIR. Quantitative evaluation was then performed in healthy adult subjects and compared with conventional DIR imaging.

Results Single-slice PS-DIR provided effective blood-signal suppression over a wide range of inversion times, enhancing wall-lumen contrast and vessel wall conspicuity for carotid arteries. Multislice PS-DIR imaging with effective blood-signal suppression is enabled.

Conclusions A variant of the PS-DIR method has successfully been implemented and tested for carotid vessel wall imaging. This technique removes timing constraints related to inversion recovery, enhances wall-lumen contrast, and enables a 3-fold increase in volumetric coverage at no extra cost in scanning time.

From the Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL); and Center for Biomedical Imaging (CIBM), Lausanne, Switzerland.

Received for publication June 21, 2014; and accepted for publication, after revision, September 15, 2014.

Conflicts of interest and sources of funding: This work was supported by the Center for Biomedical Imaging (CIBM) of the UNIL, UNIGE, HUG, CHUV, EPFL and the Leenaards and Jeantet Foundations.

The authors declare no conflicts of interest.

Reprints: Matthias Stuber, PhD, Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Center for Biomedical Imaging (CIBM), RAD-CHUV-BH07, Rue du Bugnon 46, 1011 Lausanne, Switzerland. E-mail:

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