Original ArticlesTime-Resolved Perfusion Imaging at the Angiography Suite Preclinical Comparison of a New Flat-Detector Application to Computed Tomography PerfusionJürgens, Julian H.W. MD*; Schulz, Nadine MS*; Wybranski, Christian MD*; Seidensticker, Max MD*; Streit, Sebastian MS*; Brauner, Jan MS*; Wohlgemuth, Walter A. MD†; Deuerling-Zheng, Yu MD‡; Ricke, Jens MD*; Dudeck, Oliver MD*§Author Information From the *Department of Radiology and Nuclear Medicine, University of Magdeburg, Magdeburg; †Department of Radiology, University Medical Center Regensburg, Regensburg; ‡Siemens AG, Healthcare Sector, Forchheim; and §Deutsche Akademie für Mikrotherapie, Magdeburg, Germany. Received for publication June 20, 2014; and accepted for publication, after revision, August 31, 2014. Conflicts of interest and sources of funding: Supported by a research grant from Siemens. The authors declare no conflicts of interest. Reprints: Oliver Dudeck, MD, Department of Radiology and Nuclear Medicine, University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany. E-mail: [email protected]. Investigative Radiology: February 2015 - Volume 50 - Issue 2 - p 108-113 doi: 10.1097/RLI.0000000000000107 Buy Metrics Abstract Objectives The objective of this study was to compare the parameter maps of a new flat-panel detector application for time-resolved perfusion imaging in the angiography room (FD-CTP) with computed tomography perfusion (CTP) in an experimental tumor model. Materials and Methods Twenty-four VX2 tumors were implanted into the hind legs of 12 rabbits. Three weeks later, FD-CTP (Artis zeego; Siemens) and CTP (SOMATOM Definition AS +; Siemens) were performed. The parameter maps for the FD-CTP were calculated using a prototype software, and those for the CTP were calculated with VPCT-body software on a dedicated syngo MultiModality Workplace. The parameters were compared using Pearson product-moment correlation coefficient and linear regression analysis. Results The Pearson product-moment correlation coefficient showed good correlation values for both the intratumoral blood volume of 0.848 (P < 0.01) and the blood flow of 0.698 (P < 0.01). The linear regression analysis of the perfusion between FD-CTP and CTP showed for the blood volume a regression equation y = 4.44x + 36.72 (P < 0.01) and for the blood flow y = 0.75x + 14.61 (P < 0.01). Conclusions This preclinical study provides evidence that FD-CTP allows a time-resolved (dynamic) perfusion imaging of tumors similar to CTP, which provides the basis for clinical applications such as the assessment of tumor response to locoregional therapies directly in the angiography suite. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.