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High Spatial Resolution Coronary Magnetic Resonance Angiography at 7 T: Comparison With Low Spatial Resolution Bright Blood Imaging

Bizino, Maurice B. MD*; Bonetti, Cosimo PhD; van der Geest, Rob J. PhD*; Versluis, Maarten J. PhD*; Webb, Andrew G. PhD*; Lamb, Hildo J. MD, PhD*

doi: 10.1097/RLI.0000000000000047
Original Articles

Objectives The aim of this study was to compare bright blood high spatial resolution (HR) coronary magnetic resonance angiography (MRA) with low spatial resolution (LR) bright blood coronary MRA at 7 T.

Materials and Methods Twenty-four healthy volunteers underwent navigator-gated 3-dimensional imaging of the right coronary artery at 7 T using 2 sequences: HR bright blood and LR bright blood. Image postprocessing involved newly developed multiplanar reformatting to straighten the right coronary artery. Image quality was determined by vessel edge sharpness, signal-to-noise ratio, contrast-to-noise ratio, visible vessel length, and vessel diameter.

Results Vessel edge sharpness was statistically significantly higher in HR as compared with LR (0.57 ± 0.1 vs 0.46 ± 0.06; P < 0.001), at the cost of lower signal-to-noise ratio (HR, 32.9 ± 11.0 vs LR, 112.5 ± 48.9; P < 0.001) and contrast-to-noise ratio (HR, 17.9 ± 7.4 vs LR, 50.5 ± 26.1; P < 0.001). Visible vessel length and vessel diameter were similar for both sequences (P > 0.05).

Conclusions High spatial resolution bright blood coronary MRA at 7 T is feasible and improves vessel edge sharpness as compared with LR bright blood imaging.

From the Departments of *Radiology and †Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

Received for publication July 23, 2013; and accepted for publication, after revision, January 22, 2014.

Maurice B. Bizino and Cosimo Bonetti contributed equally to this article.

Conflicts of interest and sources of funding: This work was supported by grant 01C-104 (project PREDICCt) from the Center for Translational Molecular Medicine, Eindhoven, the Netherlands.

The authors report no conflicts of interest.

Reprints: Maurice B. Bizino, MD, Department of Radiology, C3Q, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. E-mail:

© 2014 by Lippincott Williams & Wilkins