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T1 Contrast in the Myocardium and Blood Pool: A Quantitative Assessment of Gadopentetate Dimeglumine and Gadofosveset Trisodium at 1.5 and 3 T

Lin, Kai MD, MS*; Lloyd-Jones, Donald M. MD, MS; Spottiswoode, Bruce PhD; Bi, Xiaoming PhD; Liu, Ying MD, PhD; Lu, Biao MD, PhD; Xue, Huadan MD; Wang, Yining MD; Li, Debiao PhD*; Carr, James C. MD*

doi: 10.1097/RLI.0000000000000024
Technical Note

Objectives The objective of this study was to assess the evolution of T1 contrast (T1c) between cardiovascular tissues, contrast agents, and magnetic field strengths.

Materials and Methods This Health Insurance Portability and Accountability Act-compliant study was approved by the institutional review board, and written informed consent was obtained from all participants. Eight healthy volunteers were recruited to undergo 4 consecutive magnetic resonance (MR) scans with the same imaging parameters. Scans 1 and 2 were performed using a 3-T MR scanner, and scans 3 and 4 were performed using a 1.5-T MR scanner. Gadofosveset trisodium (0.03 mmol/kg) was injected for scans 1 and 3, and gadopentetate dimeglumine (Gd-DTPA) (0.1 mmol/kg) was used for scans 2 and 4. Modified Look-Locker inversion recovery T1 maps with a midventricular short-axis view were acquired before contrast and repeated every 5 minutes until 45 minutes after contrast agent administration. T1 contrast tissue (T1myocardium − T1blood), T1c agent (T1Gd-DTPA - T1Gadofosveset), and T1c field (T13T - T11.5T) were calculated and compared using t tests.

Results The T1c tissue of the 3-T scanner was larger than that of the 1.5-T scanner for both contrast agents. In both the myocardium and the blood pool, the T1c agent of the 1.5-T scanner was larger than that of the 3-T scanner. Gadofosveset trisodium exhibited a larger T1c field and T1c tissue than did Gd-DTPA. The T1c tissue induced by Gd-DTPA diminished faster than that induced by gadofosveset trisodium at both 1.5 and 3 T.

Conclusions Our study demonstrates the independent effects of timing, contrast agent type, and magnetic field strength on postcontrast T1c under general physiological conditions. The behaviors of T1c can be used to tailor quantitative MR imaging protocols for various clinical purposes.

Supplemental digital content is available in the text.

From the Departments of *Radiology, and †Preventive Medicine, Northwestern University; ‡Cardiovascular MR R&D, Siemens Healthcare, Chicago, IL; §Department of Radiology, Xijing Hospital, The Fourth Military Medical University, Peking Union Medical College, Xi’an, Shaangxi; ∥Department of Radiology, Anzhen Hospital, Capital Medical University; and ¶Department of Radiology, Peking Union Medical College Hospital, Beijing, China.

Received for publication May 21, 2013; and accepted for publication, after revision, November 4, 2013.

Conflict of interest and sources of funding: Supported by a grant from the National Institutes of Health (R01HL089695) and a grant from the American Heart Association (10CRP3050051).

Two coauthors, X.B. and B.S., are employees of SIEMENS Healthcare, Chicago, IL. The data and information of this study are under control by the authors who are not SIEMENS employee.

Current address: Biomedical Imaging Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048 (Debiao Li, PhD).

Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (

Reprints: Kai Lin, MD, MS, Department of Radiology, Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611. E-mail:

© 2014 by Lippincott Williams & Wilkins