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Diffusion-Weighted Imaging of Ocular Melanoma

Erb-Eigner, Katharina MD*; Willerding, Gregor MD; Taupitz, Matthias MD*; Hamm, Bernd MD*; Asbach, Patrick MD*

doi: 10.1097/RLI.0b013e31828eea67
Original Articles

Objectives Diffusion-weighted imaging (DWI) allows characterization of masses on the basis of their cellular density. We hypothesized that ocular melanoma has a marked diffusion restriction as seen in other malignant tumors. Furthermore, we aimed to assess whether DWI is useful to differentiate ocular melanoma from retinal detachment.

Materials and Methods The institutional review board approved the prospective study on 44 patients investigated with ocular magnetic resonance imaging including DWI during a 9-month period. A region-of-interest analysis of diffusion-weighted images with b values of 0 and 1000 s/mm2 was performed to calculate the apparent diffusion coefficient (ADC) of the ocular melanoma and the retinal detachment. Three patients were excluded because DWI was nondiagnostic owing to severe artifacts; in 1 patient, the melanoma was too small for ADC calculation. Therefore, 40 patients were included in the final analysis. Ocular melanomas and detachments were compared with respect to their ADC values. The image quality of DWI was qualitatively scored by 2 readers in consensus on a 3-point scale from 1 (minor artifacts) to 3 (major artifacts).

Results Ocular melanomas showed a marked diffusion restriction, and the mean (SD) ADC was 891 (172) × 10−6 mm2/s. Twenty-nine patients (66%) had retinal detachment. The mean ADC of the ocular melanoma differed significantly (P < 0.001) from the mean ADC of the retinal detachment (1986 [375] × 10−6 mm2/s). The image quality of DWI was rated 1 in 38 patients, 2 in 3 patients, and 3 in 3 patients.

Conclusions Ocular melanoma shows a marked diffusion restriction with an ADC of less than 1000 mm2/s, which is in concordance with other malignant tumor entities. Diffusion-weighted imaging helps differentiating ocular tumors from retinal detachment and should therefore be included in the ocular magnetic resonance imaging protocol if an ocular mass is suspected.

From the Departments of *Radiology, and †Ophthalmology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.

Received for publication November 6, 2012; and accepted for publication, after revision, February 21, 2013.

Conflicts of interest and sources of funding: none declared.

Reprints: Katharina Erb-Eigner, MD, Department of Radiology Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany. E-mail:

© 2013 by Lippincott Williams & Wilkins