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Quantification of Lung Volume at Different Tidal Volumes and Positive End-Expiratory Pressures in a Porcine Model by Using Retrospective Respiratory Gated 4D-Computed Tomography

Ley-Zaporozhan, Julia MD*‡; Ley, Sebastian MD*‡; Unterhinninghofen, Roland PhD§¶; Weinheimer, Oliver PhD*; Saito, Yasuo M.Eng; Kauczor, Hans-Ulrich MD, PhD; Szabo, Gabor MD, PhD§

doi: 10.1097/RLI.0b013e318169000e
Original Article
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Purpose: This feasibility study in healthy animals should prove the concept that it is possible to quantitatively assess the effects of different ventilatory settings on the lung parenchyma during ongoing ventilation in respiratory gated 4-dimensional (D)-computed tomography (CT). For this purpose, the influence of different tidal volumes and positive end-expiratory pressure (PEEP) on quantitative assessment of lung volumes (LVs) and lung compartments was analyzed.

Methods: Five anesthetized and ventilated (20 breaths/min, inspiratory/expiratory ratio of 1:2) healthy pigs underwent 16-row multidetector CT with retrospective respiratory gating using a noncontact charge-coupled device camera as a gating device. The device was connected to the scanner instead of the electrocardiogram gating unit. Parameters for retrospective scans were collimation 1 mm, 120 kV, 300 mA, gantry rotation time 0.5 seconds, helical pitch 2.4. Two tidal volumes (300 mL and 450 mL) and 3 PEEP levels (0, 5, and 10 cm H2O) were applied resulting in 6 scans per animal. Images were reconstructed throughout the respiratory cycle in increments of 10%. Semiautomatic segmentation provided LV, mean lung density (MLD), and different lung compartments (atelectasis, hypoventilated, normal ventilated, hyperventilated).

Results: At tidal volume 300 mL the inspiratory LV were 1.05, 1.26, and 1.5 L and expiratory LV 0.75, 0.99, and 1.24 L (PEEP 0, 5, 10 cm H2O, respectively). Differences of MLD between inspiration and expiration were 86, 65, and 46 HU. At tidal volume 450 mL, the inspiratory LV were 1.21, 1.43, and 1.72 L, and expiratory LV were 0.78, 1.01, and 1.34 L (for PEEP 0, 5, 10 cm H2O). Differences of MLD between inspiration and expiration were 109, 86, and 59 HU. A clear oscillatory wave of the normal and hypoventilated volumes was found at PEEP 0, with increase in PEEP the hypoventilated areas became increasingly normal ventilated, the amplitude of the curves decreased, and hyperventilated areas increased.

Conclusion: Using a new 4D-CT technique we were able to demonstrate the effect of different ventilation settings on the whole lung during the whole respiratory cycle. The disadvantages of static lung imaging or dynamic 2D-CT can be overcome. The possibility of quantitative evaluation of the whole lung and direct visualization and measurement of recruitment during different ventilation settings might be a great benefit for patients suffering from inhomogeneous lung injury and failure.

From the *Department of Radiology (E010), German Cancer Research Center, Heidelberg, Germany; †Department of Radiology, Johannes Gutenberg-University, Mainz, Germany; ‡Department of Pediatric Radiology, Ruprecht-Karls-University, Heidelberg, Germany; §Department of Cardiac Surgery, Ruprecht-Karls-University, Heidelberg, Germany; ¶Department of Computer Science, University of Karlsruhe, Germany; and ∥CT Systems Development Department, CT Systems Division, Toshiba Medical Systems Corporation, Tochigi, Japan.

Received May 20, 2007, and accepted for publication, after revision, September 12, 2007.

Conflict of Interest Statement: None of the authors have a financial relationship with a commercial entity that has an interest in the subject of this manuscript.

Reprints: Julia Ley-Zaporozhan, MD, Department of Pediatric Radiology, Ruprecht-Karls-University, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany. E-mail: julia.leyzaporozhan@gmail.com.

© 2008 Lippincott Williams & Wilkins, Inc.