Original ArticleRetrospective Motion Gating in Small Animal CT of Mice and RatsBartling, Soenke H. MD*†; Stiller, Wolfram MS†; Grasruck, Michael PhD§; Schmidt, Bernhard PhD§; Peschke, Peter PhD‡; Semmler, Wolfhard MD, PhD†; Kiessling, Fabian MD*† Author Information From the *Junior Group Molecular Imaging, †Department of Medical Physics in Radiology, ‡Clinical Cooperation Unit Radiotherapy, German Cancer Research Center (DKFZ), Heidelberg, Germany; and §Siemens Medical Solutions, Forchheim, Germany. Received January 30, 2007, and accepted for publication, after revision, April 14, 2007. Supported by the transregional grant “Vascular Differentiation and Remodeling” of the German Research Foundation (DFG). Reprints: Soenke H. Bartling, MD, Junior Group Molecular Imaging, Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. E-mail: [email protected]. Investigative Radiology 42(10):p 704-714, October 2007. | DOI: 10.1097/RLI.0b013e318070dcad Buy Metrics Abstract Objectives: Implementation and evaluation of retrospective respiratory and cardiac gating of mice and rats using a flat-panel volume-CT prototype (fpVCT). Materials and Methods: Respiratory and cardiac gating was implemented by equipping a fpVCT with a small animal monitoring unit. ECG and breathing excursions were recorded and 2 binary gating signals derived. Mice and rats were scanned continuously over 80 seconds after administration of blood-pool contrast media. Projections were chosen to reconstruct volumes that fall within defined phases of the cardiac/respiratory cycle. Results: Multireader analysis indicated that in gated still images motion artifacts were strongly reduced and diaphragm, tracheobronchial tract, heart, and vessels sharply delineated. From 4D series, functional data such as respiratory tidal volume and cardiac ejection fraction were calculated and matched well with values known from literature. Discussion: Implementation of retrospective gating in fpVCT improves image quality and opens new perspectives for functional cardiac and lung imaging in small animals. © 2007 Lippincott Williams & Wilkins, Inc.