Evaluation of a Newly Developed Percutaneous Thrombectomy Basket Device in Sheep With Central Pulmonary Embolisms

Abstract

Objective: 

The authors studied the development of a thrombectomy device that is adequately steerable and quickly placeable in case of extensive pulmonary embolism.

Materials and Methods: 

The device consists of a self-expandable nitinol basket mounted at a catheter-tip, which allows suction and extraction of thrombus material. Five in vitro tests were performed followed by tests in 6 sheep. In vivo thrombus material was introduced through a jugular vein to produce pulmonary embolism. After catheter insertion over the right femoral vein, the basket was placed adjacent to the pulmonary embolus and the extraction procedure was performed.

Results: 

In in vitro tests, the extracted thrombus amount varied between 60% and 95%. In animal experiments, the extracted amount varied between 30% and 95% as determined angiographically. Limiting factors were steerability and optimal positioning of the basket in relation to the embolus.

Conclusions: 

Extraction of pulmonary embolism with the self-expanding suction basket is feasible. However, successful recanalization is limited by catheter maneuverability in the pulmonary arterial system.