We sought to investigate lung volume and surface measurements during the breathing cycle using dynamic three-dimensional magnetic resonance imaging (3D MRI).
Breathing cycles of 20 healthy volunteers were examined using a 2D trueFISP sequence (3 images/second) in combination with a model and segmented 3D FLASH sequence (1 image/second) MR images using view sharing. Segmentation was performed semiautomatically using an interactive region growing technique. Vital capacity (VC) was calculated from MRI using the model (2D) and counting the voxels (3D) and was compared with spirometry.
VC from spirometry was 4.9 ± 0.9 L, 4.4 ± 1.2 L from 2D MRI measurement, and 4.7 ± 0.9 L for 3D MRI. Using the 3D technique, correlation to spirometry was higher than using the 2D technique (r > 0.95 vs. r > 0.83). Using the 3D technique, split lung volumes and lung surface could be calculated. There was a significant difference between the left and right lung volume in expiration (P < 0.05).
Dynamic 3D MRI is a noninvasive tool to evaluate split lung volumes and lung surfaces during the breathing cycle with a high correlation to spirometry.
From the *Department of Radiology, †Department of Medical and Biological Informatics, and ‡Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany.
Received August 3, 2004 and accepted for publication, after revision, November 15, 2004.
Parts of the study were supported by the German Research Council (Deutsche Forschungsgemeinschaft DFG; FOR 474).
Reprints: Christian Plathow, MD, MSc, Department of Radiology, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany. E-mail: firstname.lastname@example.org